Association between Helicobacter pylori infection and platelet count in mice
| Autor: | Kazuo Goto, Masahiko Yasuda, Teruko Fukuda, Kimiko Nogi, Eri Asou |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Helicobacter pylori infection
General Veterinary biology Inoculation business.industry Antibody titer General Medicine 030204 cardiovascular system & hematology Helicobacter pylori medicine.disease biology.organism_classification Thrombocytopenic purpura General Biochemistry Genetics and Molecular Biology Histocompatibility Andrology 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine biology.protein Animal Science and Zoology Platelet Antibody business |
| Zdroj: | Experimental Animals. 67:487-492 |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | Strong evidence for an association between idiopathic thrombocytopenic purpura (ITP) and Helicobacter pylori (HP) infection has been reported in humans. Chronic ITP is known to be improved by the eradication of HP. The purpose of this study was to reproduce these events by the experimental infection of several strains of mice with HP. BALB/c, C57BL/6, and DBA/2 mice were untreated or orally inoculated with HP. Two months later, platelet counts were compared in samples from HP-infected and noninfected mice. Platelet counts (mean ± SD, × 104 cells/µl) in blood samples from HP-infected BALB/c, C57BL/6, and DBA/2 mice were 102.28 ± 14.71, 99.65 ± 17.00, and 111.57 ± 16.20, respectively; the respective counts from noninfected mice were 121.80 ± 13.30, 104.35 ± 18.20, and 107.84 ± 14.33. A significant difference in platelet counts between HP-infected and noninfected mice was observed in BALB/c mice (P≤0.01) but was not observed in DBA/2 mice, even though the histocompatibility (H)-2 type of the DBA/2 was the same as that of BALB/c mice. According to ELISA results, the optical density value for the anti-HP antibody in HP-infected BALB/c mice was not correlated with the number of platelets (P>0.50). These results suggest that the decrease in platelet count caused by HP infection is not related to antibody titer and histocompatibility-2 type. Experimental infection of BALB/c mice with HP can reproduce the relationship between HP and ITP and serves as a good model to investigate the mechanistic basis for the effectiveness of HP eradication therapy for ITP treatment. |
| Databáze: | OpenAIRE |
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