Mesothelin and Individual Characteristics in a Cohort of Asbestos Exposed Workers
| Autor: | Andrea Bruzzone, Guglielmo Dini, S. Marcenaro, Virginia Mortara, L. Delcorso, Manlio Mencoboni, Paola Marroni, Spigno F, Luigi Michelazzi, Alex Cioè |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry Physical examination Hematology Elisa assay medicine.disease medicine.disease_cause Asbestos Oncology Internal medicine Cohort biology.protein Medicine Medical history Mesothelin Mesothelioma Occupational exposure business |
| Zdroj: | Annals of Oncology. 23:ix80 |
| ISSN: | 0923-7534 |
| DOI: | 10.1016/s0923-7534(20)32756-3 |
| Popis: | Headings The soluble mesothelin-related peptide (SMRP) is a candidate marker in the diagnosis and prognosis of mesothelioma, as well as in the screening of subjects with asbestos exposure. SMRP seems to be influenced by some individual characteristics and clinical factors. Objective The objective of this study was to evaluate the association between serum SMRP and some individual characteristics in 1704 subjects exposed to asbestos for working reasons. Design and methods Participants underwent clinical examination and were interviewed on medical history, occupational exposure, smoking and weight. SMRP was measured by a ELISA assay. Results Median SMRP was 0.45 (IQR 0.30-0.67) nmol/l. SMRP was correlated with age (p Conclusions Data on a large series of subjects with asbestos exposure confirmed that serum SMRP is associated to a number of clinical and demographic variables. Disclosure All authors have declared no conflicts of interest. |
| Databáze: | OpenAIRE |
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