Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives
| Autor: | Pavel M. Vassiliev, Denis A. Babkov, V. S. Lobasenko, A. I. Rashchenko, A. A. Brigadirova, Alexander A. Spasov, A. N. Kochetkov, Yu. V. Popov, O. S. Efremova, A. I. Kovaleva, V. A. Kuznetsova, T. K. Korchagina |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Antioxidant 010405 organic chemistry Chemistry Stereochemistry medicine.medical_treatment media_common.quotation_subject Organic Chemistry Biological activity 010402 general chemistry 01 natural sciences Biochemistry Angiotensin II 0104 chemical sciences Glycogen phosphorylase Glycation medicine Bioorganic chemistry Receptor media_common |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 43:163-169 |
| ISSN: | 1608-330X 1068-1620 |
| Popis: | New esters of N-benzoyl-3-phenoxyphenylcarboxamide acid and N-benzoyl-N′-4-bromophenyl-3-phenoxybenzamidine were synthesized. Some of the synthesized compounds were shown to inhibit the activity of dipeptidyl peptidase-4 and nonenzymatic glycosylation of proteins and manifested antiplatelet and antioxidant properties. The compounds tested did not display the antagonistic effect toward angiotensin II type 1 receptor, did not influence the activity of glycogen phosphorylase and had very little ability to break cross-links of the glycated proteins. The derivatives with the biological activity of two types were found, which can serve as basic molecules in the search for new drug products. |
| Databáze: | OpenAIRE |
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