Investigation of the hemolytic effects of various organophosphoric acid triesters (OPEs) and their structure‐activity relationship
| Autor: | Yoshitada Yoshioka, Miki Niikawa, Hideaki Kito, Hisamitsu Nagase, Kazushi Watanabe, Takahiko Sato |
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| Rok vydání: | 1997 |
| Předmět: |
Tris
Quantitative structure–activity relationship Triethyl phosphate Chemistry Health Toxicology and Mutagenesis medicine.disease Phosphate Pollution Medicinal chemistry Hemolysis chemistry.chemical_compound Toxicity medicine Environmental Chemistry Structure–activity relationship Organic chemistry EC50 |
| Zdroj: | Toxicological & Environmental Chemistry. 59:305-313 |
| ISSN: | 1029-0486 0277-2248 |
| Popis: | The hemolytic effects of various organophosphonc acid triesters (OPEs) were investigated and they showed strong hemolyic toxicity except triethyl phosphate and tris(chloroethyl)phosphate. 2‐Ethylhexyl diphenyl phosphate (EHDP) showed the strongest toxicity. By quantitative structure‐activity relationship (QSAR) study, one‐parameter regression equation to estimate hemolysis was not obtained. But, two‐parameter regression equations were obtained which were enought to estimate EC50 and EC20. The correlation coefficients with the two‐parameter regression equations were 0.939 for log(l/EC50) and 0.946 for log(l/EC20). |
| Databáze: | OpenAIRE |
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