Diversity of human U2AF splicing factors
| Autor: | Inês Mollet, Jorge Andrade, Nuno L. Barbosa-Morais, Maria Carmo-Fonseca |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Genetics
0303 health sciences Protein family 030302 biochemistry & molecular biology Alternative splicing Exonic splicing enhancer Intron Cell Biology Biology Biochemistry 03 medical and health sciences Splicing factor Splicing Factor U2AF RNA splicing snRNP Molecular Biology 030304 developmental biology |
| Zdroj: | FEBS Journal. 273:4807-4816 |
| ISSN: | 1742-4658 1742-464X |
| Popis: | U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF(65) and U2AF(35). During the past few years, a number of proteins related to both U2AF(65) and U2AF(35) have been discovered. Here, we review the conserved structural features that characterize the U2AF protein families and their evolutionary emergence. We perform a comprehensive database search designed to identify U2AF protein isoforms produced by alternative splicing, and we discuss the potential implications of U2AF protein diversity for splicing regulation. |
| Databáze: | OpenAIRE |
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