The KKAy Mouse: A Model for the Rapid Development of Glomerular Capillary Basement Membrane Thickening
| Autor: | Christina L. Connell, Mark A. Connell, Beatrice M. Wyse, Thomas J. Vidmar, G. A. Sawada, A. R. Diani, Neng Y. Zhang |
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| Rok vydání: | 1987 |
| Předmět: |
Basement membrane
medicine.medical_specialty Physiology Ratón Renal glomerulus Renal tissue Glomerulonephritis Biology medicine.disease medicine.anatomical_structure Endocrinology Glomerular capillary basement membrane Internal medicine Diabetes mellitus medicine Thickening Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of Vascular Research. 24:297-303 |
| ISSN: | 1423-0135 1018-1172 |
| Popis: | The renal tissue of 12-, 29-, 90- and 165-day-old genetically obese, hyperphagic, diabetic KKAy and age-matched nondiabetic C57BL/6 mice was morphometrically analyzed to characterize the development of peripheral glomerular capillary basement membrane thickening in the kidney of this animal model. Peripheral glomerular basement membrane (GBM) thickness was unremarkable in KKAy mice at 12 days of age (prior to onset of hyperinsulinemia) or at 29 days of age (after development of hyperinsulinemia). By 90 days of age, when the KKAy mice became severely hyperinsulinemic and hyperglycemic, the peripheral GBM thickness was greater (13%, p < 0.002) in the diabetic compared with the nondiabetic mice. Furthermore, the peripheral GBM thickness was exacerbated (20%, p < 0.001) by 165 days of age in the KKAy mice. The results of the present study suggest that peripheral glomerular capillary basement membrane thickening has an early onset and develops rapidly in the KKAy mouse in comparison with other diabetic animal models. Therefore, the KKAy mouse seems to be an appropriate model for further investigation of early structural and functional defects in the glomerular filtration barrier. |
| Databáze: | OpenAIRE |
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