HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study
| Autor: | T. Siegmund, Klaus Badenhoop, Horst Donner, B. Van der Auwera, C. Seidl, I. Weets, K. H. Usadel, J. Herwig, J. Braun |
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| Rok vydání: | 2000 |
| Předmět: |
musculoskeletal diseases
Proband medicine.medical_specialty endocrine system diseases Immunology Population Biochemistry immune system diseases Internal medicine Genetics medicine Immunology and Allergy Allele skin and connective tissue diseases education HLA-DRB1 education.field_of_study Type 1 diabetes HLA-DQB1 business.industry Haplotype Case-control study nutritional and metabolic diseases General Medicine medicine.disease business |
| Zdroj: | Tissue Antigens. 55:271-274 |
| ISSN: | 0001-2815 |
| Popis: | HLA-DR4 is a primary disease association marker in type 1 diabetes mellitus (IDDM). We therefore analyzed the transmission of 228 DR4+ haplotypes in 183 families with an IDDM proband (95 from Germany and 88 from Belgium). In a separate case-control data set, we investigated the HLA-DRB1*04 and DQ allele distribution in 245 IDDM patients and 177 controls from Germany, all DR4 positive. HLA-DRB1 *0401 and *0402 linked to DQB1 *0302 were significantly more often transmitted to patients in the studied families (81% and 89%) in contrast to DRB1 *0401-DQB1 *0301 (33%). The case-control study of HLA-DQB1 *0302+ individuals revealed -DRB1 *0405 to be more frequent in patients with IDDM and HLA-DRB1 *0403 and -DRB1 *0404 to be less frequent. HLA-DQA1 *0102-DQB1 *0602 and -DQA1 *0501-DQB1 *0301 in trans complementation with DRB1 *0401-DQB1 *0302 were also significantly less frequent in IDDM patients (P |
| Databáze: | OpenAIRE |
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