| Popis: |
Schistosomes, like most other parasitic helminths, induce strong type-2 responses in which the Th2-cell defining cytokines (IL-4, -5, -6, -13 and others) are produced by Th cells and additional cell types such as basophils and eosinophils(1)–(3). Since mice are susceptible to infection with Schistosoma mansoni, one of the major schistosome parasites of humans, and develop a disease similar to human schistosomiasis, it has been possible to use this experimental host/parasite system to ask specific questions about the induction and function of the type 2 response during infection. |
