Rasch analysis of clinical outcome measures in spinal muscular atrophy
| Autor: | Linda S. Hynan, Stefan J. Cano, Michael R. Rose, C. Berard, Leslie Nelson, Cynthia Joyce, Kristin J. Krosschell, Mackensie A. Yore, Reza Sadjadi, Kathryn J. Swoboda, Shree Pandya, Charles P. Scott, Susan T. Iannaccone, Julaine Florence, Christine Payan, Françoise Girardot, Marion Main, Eugenio Mercuri, Birgit F. Steffensen, Allan M. Glanzman, Elena S. Mazzone, Anna Mayhew, Bakri Elsheikh, John T. Kissel |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Rasch model Scale (ratio) Psychometrics Physiology Separation (statistics) Polytomous Rasch model SMA Cellular and Molecular Neuroscience Physical medicine and rehabilitation Rating scale Physiology (medical) Physical therapy medicine Neurology (clinical) Psychology Reliability (statistics) |
| Zdroj: | Muscle & Nerve. 49:422-430 |
| ISSN: | 0148-639X |
| DOI: | 10.1002/mus.23937 |
| Popis: | Introduction: Trial design for SMA depends on meaningful rating scales to assess outcomes. In this study Rasch methodology was applied to 9 motor scales in spinal muscular atrophy (SMA). Methods: Data from all 3 SMA types were provided by research groups for 9 commonly used scales. Rasch methodology assessed the ordering of response option thresholds, tests of fit, spread of item locations, residual correlations, and person separation index. Results :E ach scale had good reliability. However, several issues impacting scale validity were identified, including the extent that items defined clinically meaningful constructs and how well each scale measured performance across the SMA spectrum. Conclu- sions: The sensitivity and potential utility of each SMA scale as outcome measures for trials could be improved by estab- lishing clear definitions of what is measured, reconsidering items that misfit and items whose response categories have |
| Databáze: | OpenAIRE |
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