| Autor: |
Laura Collins, Leslie P. Hughes, Stephen A.C. Wren, Ian C. Jones |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Pharmaceutical Sciences. 110:3546-3549 |
| ISSN: |
0022-3549 |
| Popis: |
We report what we believe is the first use of 19F NMR spectroscopy to directly measure in-vitro release (IVR) from polymeric nanoparticles (PNPs). Using 19F NMR we selectively measured IVR of AZD2811 from PNPs. Due to rapid nuclear relaxation in solid-like environments only AZD2811 in solution is detected, and physical separation from the PNPs isn't required. The NMR approach and ultra-centrifugation/UHPLC were shown to be equivalent. The selectivity of 19F NMR means it is readily applied to complex IVR media such as recombinant human serum albumin (rHSA). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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