Conventional versus reverse sequence of neoadjuvant epirubicin/cyclophosphamide and docetaxel: sequencing results from ABCSG-34

Autor: Paul Sevelda, Marija Balic, Raimund Jakesz, Rupert Bartsch, Margaretha Rudas, Zsuzsanna Bago-Horvath, Martin Filipits, Georg Pfeiler, Angelika Pichler, Sophie Frantal, Austrian Breast, Christoph Tinchon, Florian Fitzal, Tea Maria Muy-Kheng, Vesna Bjelic-Radisic, Herbert Stoeger, Andreas L. Petzer, Peter Dubsky, Christian F. Singer, Edgar Petru, Ruth Exner, Richard Greil, Viktor Wette, Daniel Egle, Michael Hubalek, Michael Gnant
Rok vydání: 2021
Předmět:
Zdroj: British Journal of Cancer. 124:1795-1802
ISSN: 1532-1827
0007-0920
DOI: 10.1038/s41416-021-01284-2
Popis: Background Preoperative chemotherapy containing anthracyclines and taxanes is well established in early-stage breast cancer. Previous studies have suggested that the chemotherapy sequence may matter but definitive evidence is missing. ABCSG trial 34 evaluated the activity of the MUC1 vaccine tecemotide when added to neoadjuvant treatment; the study provided the opportunity for the second randomisation to compare two different anthracycline/taxane sequences. Methods HER2-negative early-stage breast cancer patients were recruited to this randomised multicentre Phase 2 study. Patients in the chemotherapy cohort (n = 311) were additionally randomised to a conventional or reversed sequence of epirubicin/cyclophosphamide and docetaxel. Residual cancer burden (RCB) with/without tecemotide was defined as primary study endpoint; RCB in the two chemotherapy groups was a key secondary endpoint. Results No significant differences in terms of RCB 0/I (40.1% vs. 37.2%; P = 0.61) or pathologic complete response (pCR) rates (24.3% vs. 25%, P = 0.89) were observed between conventional or reverse chemotherapy sequence. No new safety signals were reported, and upfront docetaxel did not result in decreased rates of treatment delay or discontinuation. Conclusion Upfront docetaxel did not improve chemotherapy activity or tolerability; these results suggest that upfront neoadjuvant treatment with anthracyclines remains a valid option.
Databáze: OpenAIRE
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