Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial
| Autor: | Arezoo Ahmadi, Seyyed Mahdi Rajaee, George E. Barreto, Atabak Najafi, Shiva Ganjali, Mohammadreza Gheini, Amirhossein Sahebkar, Mohammad Sharifzadeh, Mohammad Abdollahi, Mojtaba Mojtahedzadeh, Yunes Panahi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
medicine.medical_treatment Ischemia Atrial fibrillation medicine.disease Amiodarone Placebo Neuroprotection law.invention 03 medical and health sciences 0302 clinical medicine Bolus (medicine) Randomized controlled trial law Anesthesia medicine 030212 general & internal medicine business Saline medicine.drug |
| Zdroj: | Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health ISBN: 9783030648718 |
| DOI: | 10.1007/978-3-030-64872-5_28 |
| Popis: | Anti-arrhythmic agents, like amiodarone, interfere at different stages of the ischemic stroke. However, amiodarone was accompanied with immunological pulmonary complications and adverse neurological effects. We hypothesize that magnesium sulfate in combination with amiodarone holds promise for stroke treatment. Thirty-six patients with confirmed diagnosis of ischemic stroke and atrial fibrillation who received bolus amiodarone were randomly assigned to magnesium sulfate every 24 h or similar volume of normal saline (as placebo) for 5 days. Various severity test scores were used to evaluate the symptoms. Routing biochemistry were also measured at days 1 and 5. Treatment with MgSO4 results in a significant reduction in serum levels of NGAL, Hb, T.Bill, IL-6, IL-8, SNSE, S100B, EGF, PAF, CRP and IgG. Also, MgSO4 treatment significantly improved the RASS, Candida, SOFA, NIHSS and APACHE scores. Moreover, reduction of IL-6, IL-8, SNSE, EGF and APACHE score and increase in RASS score were significantly higher in MgSO4 group compared with placebo. Intravenous administration of MgSO4 in amiodarone-treated stroke patients improved the inflammatory, immunological and neurological indicators and reduced disability in ICU-admitted AIS patients, suggesting that this treatment scheme may prevent amiodarone-induced complications in these patients. |
| Databáze: | OpenAIRE |
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