Prevention of Experimental Uterine Bleeding in Macacus Monkey by Corpus Luteum Extract (Progestin)
| Autor: | P. E. Smith, E. T. Engle |
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| Rok vydání: | 1932 |
| Předmět: | |
| Zdroj: | Experimental Biology and Medicine. 29:1225-1227 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-29-6293 |
| Popis: | Since uterine bleeding was shown to follow cessation of follicular treatment, the many observations on experimental menstruation in the monkey have not given adequate consideration to the role of the corpus luteum. Experiments were designed to study this question. Adult or subadult animals, all beyond the first menstruation (3700 to 5150 gm. B.W.) were injected with the follicle stimulating water soluble fraction of sheep pituitaries (Pyridine method of Fevold, Hisaw and Leonard) for 10 to 14 days. Coincident with the last 4 of these injections oestrin (Theelin) was also given in large doses (100 R.U. per diem)∗∗. The uterus at the end of the treatment was large, firm and of a deep red color. It is known that the animal will bleed within 6 days of the cessation of this treatment. Bilateral ovariectomy was also performed, which alone will be followed by uterine bleeding. On this day of ovariectomy, treatment was begun with Progestin (method of Corner and Allen), giving generally 70 gm. equivalent of fresh ... |
| Databáze: | OpenAIRE |
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