15 The Effects of Hyperglycemia on Newborn Endothelial Progenitor Cells

Autor:	David A. Ingram, Laura S. Haneline, E Dropcho, Laura E. Mead, Izlin Z. Lien
Rok vydání:	2006
Předmět:	Senescence medicine.medical_specialty Vascular disease Angiogenesis Biology medicine.disease Vascular endothelial growth factor B Endocrinology Apoptosis Internal medicine Diabetes mellitus Pediatrics Perinatology and Child Health medicine Progenitor cell Risk factor
Zdroj:	Pediatric Research. 60:493-493
ISSN:	1530-0447 0031-3998
Popis:	Purpose of Study: Diabetes Mellitus (DM) is the most prevalent risk factor for acquiring vascular disease. Since optimal glycemic control delays onset and progression of vascular morbidities, hyperglycemia is hypothesized to be a key pathogenic factor for vasculopathies. Vascular integrity requires endothelial repair and angiogenesis. Recently, circulating endothelial progenitor cells (EPCs) were shown to have a critical role in promoting endothelial repair and angiogenesis. Given that infants exposed to a diabetic intrauterine environment have an increased risk of DM and vascular disease, we hypothesize that hyperglycemia alters neonatal EPC function. Thus, our aims were to examine the effect of hyperglycemia on newborn EPC clonogenic capacity, proliferative potential, apoptosis, senescence, and capillary tube formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8fffbee0cf0dde2df7230a0559ce5d89 https://doi.org/10.1203/00006450-200610000-00037 Zobrazit plný text záznamu