Effect of TFC-612, a 7-thia prostaglandin El derivative, on intimal thickening after endothelial injury with balloon catheter in rats
| Autor: | Yukio Motoyama, Mie Nishio, Keizo Yoshida, Yasuko Katoh, Jiro Seki |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Aorta Endothelium Smooth muscle cell migration biology Chemistry Growth factor medicine.medical_treatment Balloon catheter Prostaglandin Anatomy chemistry.chemical_compound Endocrinology medicine.anatomical_structure medicine.artery Internal medicine medicine biology.protein Cardiology and Cardiovascular Medicine Bromodeoxyuridine Platelet-derived growth factor receptor |
| Zdroj: | Atherosclerosis. 108:159-165 |
| ISSN: | 0021-9150 |
| Popis: | The effect of TFC-612, methyl-6-[{(1 R ,2 S ,3 R )-3hydroxy-2-{(l E ,3 S ,5 R )-3-hydroxy-5-methyl-l-nonenyl}-5-oxocyclopentyl}thio] hexanoate, on intimal thickening of carotid artery 14 days after endothelium denudation with a balloon catheter was examined in rats. This compound significantly suppressed the neointimal area and the ratio of intimal and medial layer by 41.1% and 31.4%, respectively, at 3.2 μg/rat/h s.c. infusion. At this dose, this compound did not inhibit platelet aggregation induced by either collagen or ADP. It did not inhibit bromodeoxyuridine incorporation into medial smooth muscle cells at 3 days after injury. In in vitro experiments, TFC-612 did not inhibit the [ 3 H]thymidine uptake into cultured smooth muscle cells, but it showed significant inhibition of smooth muscle cell migration induced by platelet-derived growth factor (PDGF) at more than 10 −9 M. This compound increased cyclic AMP levels dose dependently in cultured smooth muscle cells at more than 10 −8 M. These results suggest that TFC-612 inhibits intimal thickening by inhibition of smooth muscle cell migration from media to intima through cyclic AMP elevation. |
| Databáze: | OpenAIRE |
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