A shear cell study on oral and inhalation grade lactose powders
| Autor: | Ciro Cottini, Andrea Benassi, Roberto Bosi, A. Ghiretti, R. Gaspari, G. Cavalli |
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| Rok vydání: | 2020 |
| Předmět: |
Mathematical relationship
Materials science Inhalation General Chemical Engineering Lactose Powder 02 engineering and technology 021001 nanoscience & nanotechnology Shear cell chemistry.chemical_compound 020401 chemical engineering chemistry Particle size 0204 chemical engineering Lactose Composite material 0210 nano-technology |
| Zdroj: | Powder Technology. 372:117-127 |
| ISSN: | 0032-5910 |
| DOI: | 10.1016/j.powtec.2020.05.041 |
| Popis: | Shear cell tests have been conducted on twenty different lactose powders, most of which commercially available for oral or inhalation purposes, spanning a wide range of particle sizes, particle morphologies, production processes. The aims of the investigation were: i) to verify the reliability of the technique in evaluating and classifying the flowability of powders; ii) to understand the connection between the flowability of a powder and the morphological properties of its particles; iii) to find a general mathematical relationship able to predict the yield locus shape given the particle size, shape and consolidation state of a lactose powder. These aspects and their limitations are detailed in the manuscript together with other interesting findings on the stick-slip behavior observed in most of the lactose powders examined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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