Dynamics of Membrane Proteins
| Autor: | Sahil Lall, Mathew K. Mathew |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology FERM domain biology Chemistry Peripheral membrane protein Biological membrane Membrane transport 03 medical and health sciences Mitochondrial membrane transport protein 030104 developmental biology Membrane protein Biophysics biology.protein Protein–lipid interaction Integral membrane protein |
| Zdroj: | Springer Series in Biophysics ISBN: 9783319666006 |
| DOI: | 10.1007/978-3-319-66601-3_10 |
| Popis: | Transmembrane proteins inhabit a highly asymmetric environment that is, to a first approximation, two-dimensional. Many of them serve to transmit information between aqueous compartments, while others serve as conduits for the transport of material between compartments. In serving these functions they have to adopt at least two stable structures and rapidly interconvert between them. The paucity of atomic resolution structures has been limiting in elucidating the mechanisms by which these proteins carry out their functions. However, this century has seen the determination of the three-dimensional structures of a number of membrane proteins, leading to the start of an understanding of the dynamics displayed by them within the bilayer. Without attempting to be exhaustive, we provide illustrative examples of dynamics in membrane proteins and review their underlying mechanisms as they insert, fold and function in biological membranes. |
| Databáze: | OpenAIRE |
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