DEVELOPMENT AND EVALUATION OF A POLOXAMER- AND CHITOSAN-BASED IN SITU GEL-FORMING INJECTABLE DEPOT

Autor:	Nazia Begum, Hema a Nair
Rok vydání:	2020
Předmět:	Pharmacology Gel forming Chitosan In situ chemistry.chemical_compound chemistry Chemical engineering Depot Pharmaceutical Science Pharmacology (medical) Poloxamer
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :36-41
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2020.v13i4.36687
Popis:	Objective: The present study is intended to investigate the applicability of poloxamer- and chitosan-based temperature induced in situ injectable gelling depot for once a week therapy as an intramuscular injection employing olanzapine as a model drug. Methods: The thermosetting gel was prepared by admixture of a solution of poloxamer P127 and a solution of olanzapine and chitosan in aqueous acetic acid. The resultant formulation was characterized for gelation temperature, gelation time, viscosity, syringeability, pH, drug content, and in vitro drug release. The in vitro release of olanzapine from the gelled depot was followed using USP paddle type II apparatus in conjunction with a dialysis bag. The gel was injected ex vivo into chicken muscle and observed by subsequent dissection. Results: The formulation was designed to have a phase transition temperature of 34°C and gelled in
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8fc975b68737d16ffa81cfbadcf0deb4 https://doi.org/10.22159/ajpcr.2020.v13i4.36687 Zobrazit plný text záznamu