Specific control of cell–material interactions: Targeting cell receptors using ligand-functionalized polymer substrates
| Autor: | Andrew Edwin Rodda, David R. Nisbet, Laurence Meagher, John S. Forsythe |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Bioconjugation Materials science Polymers and Plastics Peptidomimetic Ligand Organic Chemistry Peptide Surfaces and Interfaces Raft Förster resonance energy transfer chemistry Biochemistry Materials Chemistry Ceramics and Composites Biophysics Receptor PI3K/AKT/mTOR pathway |
| Zdroj: | Progress in Polymer Science. 39:1312-1347 |
| ISSN: | 0079-6700 |
| DOI: | 10.1016/j.progpolymsci.2013.11.006 |
| Popis: | Cells respond to their environment in complex and sometimes poorly understood ways. Protein, peptide and synthetic peptidomimetic ligands may all be used to stimulate cells via receptor signaling, using interactions that are often highly specific. Polymer substrates that present these ligands provide a promising way to control cell development, both for applications in biotechnology and for fundamental studies of cell biology. Here we review a large range of techniques that have been employed to create and characterize ligand-functionalized substrates, with a particular focus on techniques that allow specific and consistent stimulation. |
| Databáze: | OpenAIRE |
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