Adrenergic Control of Interdigestive and Digestive Motility via the Pyloric Region
| Autor: | K. Milenov, W. Forth, G. E. Holle |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Endocrine and Autonomic Systems Physiology digestive oral and skin physiology Gastroenterology Motility Adrenergic Biology Pylorus digestive system Endocrinology Phentolamine medicine.anatomical_structure Internal medicine medicine Retching Pyloric region medicine.symptom Antrum Migrating motor complex medicine.drug |
| Zdroj: | Neurogastroenterology & Motility. 3:131-137 |
| ISSN: | 1350-1925 |
| Popis: | This study examines the influence of an α-adrenergic blocking drug, phentolamine, on inter digestive and digestive motility when given intraarterially, close to the pylorus. In seven mongrel dogs four extraluminal bipolar platinum electrodes and four strain-gauge force transducers were placed at the antrum and proximal duodenum and three mini strain gauges and one electrode at the pyloric ring. After two migrating motor complexes (MMCs) were registered the drug was applied through a catheter inserted via the arteria gastroomentalis dextra to the pylorus, during phase I, the middle and end of phase II of the MMC, and 15 to 25 minutes after a meat meal. Local α-adrenergic blockade of the pylorus caused immediate conversion of phase I to phase II of the MMC, with significant prolongation of phase II, broadening of antral and pyloric contractions, and in some animals giant contractions with vomiting and retching. The pyloric motility index in phase III increased up to 22%. It prolonged phase II by 237%. Phentolamine after the meat meal caused an increase in motility index, mainly in the pylorus, while the increase in contraction frequency was less pronounced. The results indicate inhibitory adrenergic control of the interdigestive motor pattern and digestive motility in the pyloric region. |
| Databáze: | OpenAIRE |
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