Splenopentin: A modulator of immune and behavioral reactions in a secondary immunodeficiency state induced by experimental alcoholism

Autor:	P. Oeme, V. G. Fomina, K. Forner, H. Repke, J. Odarjuk, V. A. Evseev, T. V. Davydova
Rok vydání:	1991
Předmět:	Microgram Phagocytosis General Medicine Pharmacology Biology medicine.disease General Biochemistry Genetics and Molecular Biology Secondary immunodeficiency Alcohol intoxication Immune system Antigen Immunity Splenopentin Immunology medicine
Zdroj:	Bulletin of Experimental Biology and Medicine. 111:840-842
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00840199
Popis:	Effect of splenopentin on some patterns of immunity was studied in mice with chronic alcoholic intoxication. Splenopentin was administrated into animals once intraperitoneally (250 micrograms/kg). Administration of splenopentin was found to normalize several immunological patterns in animals with chronic alcoholic intoxication: the immune response to the thymus-dependent antigen sheep red blood cells and phagocytic activity of peritoneal macrophages. Also observations over C57B1/6 mice characterized by high level of alcoholic motivation showed that alcohol consumption in mice decreased after administration of splenopentin at a dose of 250 micrograms/kg during two weeks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8fb86d64949d1c193c09960f43684a4b https://doi.org/10.1007/bf00840199 Zobrazit plný text záznamu Full text from SpringerLink