In colon cancer, normal colon tissue and blood cells have altered telomere lengths

Autor:	Joan Viñas‐Salas, Cristina Valls-Bautista, Josep Maria Reñé-Espinet, Carme Piñol-Felis, Juan Buenestado-García
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Colorectal cancer Normal colon Colonoscopy General Medicine medicine.disease Telomere Colonic mucosa Oncology Body cells Medicine Surgery business Inverse correlation Normal control
Zdroj:	Journal of Surgical Oncology. 111:899-904
ISSN:	0022-4790
DOI:	10.1002/jso.23894
Popis:	Background: Telomere length (TL) shortened occurs in colorectal carcinogenetic process. Our objective is to determine if it is only a local fact or there are alterations in normal colon cells and in other body cells. Methods: TL of tumoral and normal mucosa and leukocytes of 40 patients operated of colorectal cancer (CRC) and 40 control patients with normal colonoscopy were measured by Southern-blot. Groups were matched by the same localization as tumors, sex, and age. Results: In CRC patients, TRFL (Telomere Repeat Factor Length) leukocytes mean was 8.84 kpb, normal colonic mucosa 7.97 kpb, and tumoral mucosa 7.33 kpb (P
Databáze:	OpenAIRE
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