Synthesis, Characterisation, and in Vitro Antibacterial Evaluation of a New Class of 2-substituted-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a] Pyrimidines

Autor:	Marzieh Akbarzadeh, Kayvan Saadat, Yasaman Etemadi, Hamid Beyzaei, Hossein Eshghi, Ali Shiri, Sarina Sadat Mozafari, Mohammadreza Moghaddam-Manesh
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Chloroform chemistry 010405 organic chemistry General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry In vitro 0104 chemical sciences
Zdroj:	Journal of Chemical Research. 40:600-603
ISSN:	2047-6507 1747-5198
DOI:	10.3184/174751916x14737838285904
Popis:	The reaction of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with 4,5-dihydrothiazol-2-amine in chloroform led to the formation of 2-chloro-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidine (3). The true structure of the target compound was confirmed by density functional theory calculations of condensed Fukui indices. The substitution of the 2-Cl function in compound 3 with different secondary amines yielded 2-substituted-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidines in good yields. The assigned products were tested for their potential antibacterial activity and the results indicated that a few derivatives are valuable compounds with great potential to be used as antibacterial agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8fb0f531b0605aac7cd2eb135db537c4 https://doi.org/10.3184/174751916x14737838285904 Zobrazit plný text záznamu Plný text ve formátu PDF