Phenylboronic acid-conjugated cationic methylcellulose for hepatocellular carcinoma-targeted drug/gene co-delivery systems
| Autor: | Ju Hyeon Jeon, Tae-il Kim, Jaehong Park |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Polyethylenimine
General Chemical Engineering Cationic polymerization 02 engineering and technology Transfection 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry Reductive amination 0104 chemical sciences chemistry.chemical_compound chemistry parasitic diseases medicine Asialoglycoprotein receptor Doxorubicin Phenylboronic acid 0210 nano-technology Cytotoxicity medicine.drug |
| Zdroj: | Journal of Industrial and Engineering Chemistry. 75:148-157 |
| ISSN: | 1226-086X |
| DOI: | 10.1016/j.jiec.2019.03.016 |
| Popis: | Phenylboronic acid-conjugated cationic methylcellulose (MCPEI-PBA) was synthesized and characterized for hepatocellular carcinoma-targeted drug/gene co-delivery systems. MCPEI-PBA was obtained by reductive amination of polyethylenimine 2k to oxidized methylcellulose and conjugation of PBA. MCPEI-PBA could form nano-aggregates via B–N coordinate bonding and hydrophobic interaction and also form positively charged and nano-sized polyplexes. Cytotoxicity of MCPEI-PBA was low and MCPEI-PBA showed higher transfection efficiency than PEI25k in hepatocellular carcinoma. Galactose pretreatment experiment suggested its specific interaction with asialoglycoprotein receptors. MCPEI-PBA could encapsulate doxorubicin (Dox) efficiently. Finally, MCPEI-PBA/Dox/pJDK-apoptin complexes showed high anticancer activity due to the combinatorial effect of Dox and expressed apoptin. |
| Databáze: | OpenAIRE |
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