Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease
| Autor: | Ronald C. Petersen, Jennifer L. Whitwell, Clifford R. Jack, Jonathan Graff-Radford, Daniel A. Drubach, Stephen D. Weigand, Prashanthi Vemuri, David S. Knopman, David T.W. Jones, Mary M. Machulda, Nilufer Ertekin-Taner, Nirubol Tosakulwong, Matthew L. Senjem, Keith A. Josephs, Anthony J. Spychalla, Bradley F. Boeve, Val J. Lowe |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Amyloid Epidemiology Correlation 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Atrophy Developmental Neuroscience Neuroimaging Medicine medicine.diagnostic_test business.industry Health Policy Posterior cortical atrophy Magnetic resonance imaging medicine.disease Psychiatry and Mental health 030104 developmental biology chemistry Positron emission tomography Neurology (clinical) Geriatrics and Gerontology business Pittsburgh compound B 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia. 14:1005-1014 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2018.02.020 |
| Popis: | Introduction Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear. Methods We assessed subject-level regional correlations between tau on [ 18 F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [ 18 F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry. Results [ 18 F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [ 18 F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [ 18 F]AV-1451 uptake and cortical thickness. Discussion These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants. |
| Databáze: | OpenAIRE |
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