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Keywords: alimentary stomatitis, high-fat diet, dysbiosis, antidisbiotic agent. Aim: тo investigate the prophylactic effect of the antidisbiotic phytopreparation kvertulin on the condition of the oral mucosa (OM) of rats with alimentary stomatitis. Methods. Alimentary stomatitis was reproduced in rats fed with 15% palm oil and with drinking water - lincomycin. After 40 days of feeding the rats, the activity of elastase, catalase, urease, lysozyme, and the content of malondialdehyde (MDA) were determined in the OM. The antioxidant-prooxidant index (API) was calculated from the ratio of catalase activity and MDA content, and the degree of dysbiosis was calculated from the ratio of relative urease and lysozyme activities. Results: In rats that consumed palm oil on the background of dysbiosis, the level of elastase, MDA, urease in OM significantly increased and the level of catalase and lysozyme decreased.The API index also decreases, but the degree of dysbiosis increases. In rats treated with palm oil on the background of dysbiosis and at the same time phytopreparation kvertulin, the levels of elastase, MDA, urease decreased in OM, but the level of catalase, lysozyme, API index significantly increased. The degree of dysbiosis was significantly reduced. Conclusion. Prevention of alimentary stomstitis by preparation kvertulin equal to 34 %. |
