| Popis: |
Samarium-153 (153Sm) is widely used in radiation synovectomy and pain management of bone metastases. It emits 103 keV gamma radiation suitable for imaging, providing an alternative for therapy with pure beta emitter, especially liver radioembolization using Yttrium-90 (90Y). This study investigated 153Sm theranostics (therapy plus diagnostic) properties for unresectable liver tumor. The cation-exchange resin, Amberlite IR-120H + (Sigma-Aldrich, USA) commercially available as beads (620-830 μm), was crushed and sieved to 20- 40 μm, and labelled with 152SmCl3 prior to neutron activation. 3 GBq 153Sm activity was aimed based on 90Y SIR-Spheres standard activity. The samples were irradiated in 1.494 x 1012 n.cm− 2.s− 1 neutron flux for 6 h. Microparticles characterization, gamma spectroscopy, and in-vitro radiolabelling studies were carried out and compared to Fractogel EMD SO3- (S) (Merck, Germany), commercially made in 20-40 μm. Fourier Transform Infrared (FTIR) spectroscopy of Sm-Amberlite showed unaffected functional groups, following size reduction of the beads. However, as shown by the electron microscope, the microparticles were irregular in shape. The radioactivity achieved after 6 h neutron activation was 3.104 ± 0.029 GBq. The specific activity per microparticle for 153Sm-Amberlite and 153Sm-Fractogel were 55 Bq and 49 Bq, respectively. Gamma spectroscopy showed no radioactive impurities in 153Sm- Amberlite but there was a detectable amount of 24Na in 153Sm- Fractogel. Energy-dispersive X-ray (EDX) spectroscopy of 153Sm-Fractogel showed presence of chlorine (Cl) impurity but no significant impurities were observed in 153Sm-Amberlite. Radiolabeling efficiency of 153Sm-Amberlite in distilled water and blood plasma over 48 h were excellent and better than 153Sm-Fractogel. 153Sm-Amberlite is suitable as alternative to 90Y, with advantage of post-procedure imaging. |
