Ecto-5′-Nucleotidase (E5′-NT, 27.2, CD73), 27.1, Leu13, CD28 and LAM-1(Leu8) Antigens in Mycosis Fungoides (MF)

Autor:	Maurice Barcos, Linda F. Thompson, Howard L. Stoll, Charlotte Pollard, Robert L. Evans
Rok vydání:	1992
Předmět:	Cancer Research Mycosis fungoides Pathology medicine.medical_specialty medicine.drug_class CD28 Hematology Biology medicine.disease Monoclonal antibody 5'-nucleotidase Lymphoma Leukemia Oncology Antigen immune system diseases hemic and lymphatic diseases medicine IL-2 receptor
Zdroj:	Leukemia & Lymphoma. 6:503-511
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428199209053590
Popis:	Two monoclonal antibodies (MoAbs) B121 and B124 to the human lymphocyte differentiation antigen E5′-NT (CD73), and the MoAbs 27.2 and 27.1 that were raised to HTLV-1+CD4+CD25+ leukemic T cells were tested immunohistochemically on frozen sections of 13 cases of MF together with Leu13, CD28, LAM-1(Leu8) and other standard T-cell markers. Controls included 7(5T, 2B) non-MF cutaneous non-Hodgkin's lymphomas (NHL), 2 cutaneous T lymphoid leukemias (T-ALL), 13 miscellaneous non-neoplastic dermatoses, 11(5T, 6B) extracutaneous NHL, and 5 splenic B-hairy cell leukemias. Previous studies suggest that 27.2 also recognizes the CD73 antigen and is present in high density in some cases of HTLV-1+ adult thymic leukemia/lymphoma (ATL) and HTLV-1- Sezary syndrome (Y. Fukunaga et al., Blood 74:2486-2492, 1989). In the studies reported here B121, B124 and 27.2 reacted similarly with the MF and control samples tested. The CD73 antigen was present in the majority of lymphoid cells from 8 (62%) of 13 cases of MF. In one of th...
Databáze:	OpenAIRE
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