Influence of the Activation of NMDA Receptors on the Resting Membrane Potential of the Postsynaptic Cell at the Neuromuscular Junction
| Autor: | S. E. Proskurina, Evgeny E. Nikolsky, Konstantin A. Petrov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Membrane potential Chemistry Neuromuscular transmission Excitotoxicity Glutamate receptor medicine.disease_cause Biochemistry Neuromuscular junction 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Synaptic plasticity medicine Molecular Medicine NMDA receptor Receptor Molecular Biology Neuroscience Biotechnology |
| Zdroj: | Acta Naturae. 10:100-102 |
| ISSN: | 2075-8251 |
| DOI: | 10.32607/20758251-2018-10-3-100-102 |
| Popis: | Impaired function or insufficient expression of glutamate N-methyl-D-aspartate (NMDA) receptors underlies a number of brain pathologies; these receptors are, therefore, regarded as a pharmacological target for many neuroactive drugs. It was shown that in the CNS, this type of glutamate receptors participate in the processes of neuronal excitation, synaptic plasticity [1, 2], and excitotoxicity in neurodegenerative diseases and are also involved in the pathogenesis of epilepsy and seizures. However, until recently, the presence and activity of NMDA receptors beyond the CNS had never been considered. This research shows that activation of NMDA receptors at the mammalian neuromuscular junction alters the resting membrane potential of the postsynaptic cell evoked by cation entry through the receptor-associated channel. |
| Databáze: | OpenAIRE |
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