Water-catalyzed crystallization of amorphous acadesine

Autor:	Daniel J. B. Hemming, Melissa J Larsen, Ray W. Wood, Robert G. Bergstrom, Lee D. Hansen
Rok vydání:	1997
Předmět:	Chemistry Analytical chemistry food and beverages Pharmaceutical Science Partial pressure humanities Amorphous solid law.invention Crystal law Anhydrous Organic chemistry Relative humidity Crystallization Hydrate Water vapor
Zdroj:	International Journal of Pharmaceutics. 154:103-107
ISSN:	0378-5173
DOI:	10.1016/s0378-5173(97)00095-1
Popis:	Lyophilized, amorphous acadesine crystallizes when exposed to water vapor. Isothermal calorimetry of samples held at constant humidity showed crystallization always occured within 1.5 h at relative humidities above about 50%, but was never observed at humidities below about 40%. The crystalline phase is anhydrous. Crystallization must proceed through an intermediate, metastable hydrate that immediately decomposes to the anhydrous crystal, a mechanism not commonly considered. The various possible mechanisms of water-catalyzed crystallization of amorphous materials can be distinguished by the dependence of the initiation time on the partial pressure of water vapor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8f8030e1e45e9956a84bd648c0b70713 https://doi.org/10.1016/s0378-5173(97)00095-1 Zobrazit plný text záznamu Full Text from ScienceDirect