The Long Term Chemotherapy with Erythromycin (EM) in Chronic Lower Respiratory Tract Infections
| Autor: | Keiichi MIKASA, Masayoshi SAWAKI, Mitsuru KONISHI, Koichi MAEDA, Shoji TAKEUCHI, Kaoru HAMADA, Mikikazu KUNIMATSU, Takayuki MASUTANI, Reiko SANO, Eiji KITA, Shuzo KASHIBA, Nobuhiro NARITA |
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| Rok vydání: | 1992 |
| Předmět: |
Chemotherapy
medicine.medical_specialty Exacerbation Respiratory tract infections business.industry medicine.medical_treatment Erythromycin General Medicine medicine.disease Gastrointestinal disorder Quality of life Anesthesia Internal medicine medicine business Stomatitis medicine.drug Cause of death |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 66:561-567 |
| ISSN: | 1884-569X 0387-5911 |
| Popis: | An investigation was made of the use of EM therapy which began in 1986 or earlier in 31 cases with chronic lower respiratory tract infections. 1) Of the 20 cases in which EM (Erythromycin stearate) administration (600-1200 mg/day) was continued for 3 years or more and its usefulness could be evaluated, treatment with this agent was judged markedly effective in three, effective in 14, somewhat effective in two, and ineffective in one. This amounted to an effectiveness rate (effective or better) of 85%. 2) Improved QOL was observed in 15 of the 20 cases. 3) In the Pseudomonas infected cases, a discrepancy was seen between the effectiveness rate of 87.5% and the disappearance rate of the organism (12.5%), while in the Haemophilus cases no such discrepancy was found (75%). 4) EM administration was stopped in 11 cases because of side effects in two (stomatitis, gastrointestinal disorder) death in five, desire of the patient in three, and transfer to another hospital in one. The cause of death cases had no connection with administration of EM. 5) In the three patients who stopped EM on their own, the agent was again administered because of exacerbation of symptoms, although this readministration proved ineffective in two of the cases. The above results suggest that long term EM therapy is useful and that its continued administration is important. |
| Databáze: | OpenAIRE |
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