Protective Effects of the Polyphenolic-Rich Fraction of Cornsilk against Oxidative Stress in Streptozotocin-Induced Diabetic Rats
| Autor: | Nurraihana Hamzah, Sabreena Safuan, Wan Rosli Wan Ishak |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Jurnal Gizi dan Pangan. 18:41-50 |
| ISSN: | 2407-0920 1978-1059 |
| Popis: | Diabetes Mellitus (DM) has become a significant public health problem worldwide and primarily correlated to hyperglycaemia and abnormal lipid and antioxidant levels. Fruit and vegetable wastes are rich in phenolic compounds thus suitable for antioxidant sources. Cornsilk (CS), a maize cultivar waste, also contains phenolic compounds. The current study investigated the anti-hyperglycemic and antioxidative properties of the Phenolic-Rich Fraction of Cornsilk (PRF-CS) in Streptozotocin (STZ)-induced diabetic rats. Five groups of 30 male Sprague Dawley rats were employed in this study. A sample size of six rats each is placed in five groups: Normal-Control (NC), Diabetic-Control (DC), Diabetic-PRF-CS treated 100 mg/kg (DPRF100) and 200 mg/kg (DPRF200), and Diabetic-Metformin Treated (Dmet) groups. The PRF-CS was administered at 100 and 200 mg/kg doses for 28 consecutive days to the diabetic rats. Treatment with both doses of PRF-CS (DPRF100 and DPRF200) significantly decreased the blood glucose levels of the rats (p |
| Databáze: | OpenAIRE |
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