Direct alkylation of pyrrole with vinyl substituted aromatics: versatile precursors for the synthesis of porphyrinoid macrocycles

Autor:	Juyoung Yoon, Chang-Hee Lee, Jong Seung Kim, Seung Doo Jeong, Jaeduk Yoo, Seong Jin Hong
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Chemistry Organic Chemistry Drug Discovery Thiophene Organic chemistry Lewis acids and bases Alkylation Biochemistry Pyrrole
Zdroj:	Tetrahedron Letters. 49:4138-4141
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2008.04.119
Popis:	5-Substituted dipyrromethane analogues ( 8 ), ( 23 ) and ( 25 ) were synthesized by the reaction of 2-vinylpyrroles, 2-vinylthiophene or 2-vinylbenzenes with excess pyrrole in the presence of Lewis acids. Accordingly, tripyrromethane analogues could be obtained by starting with 2,5-divinyl thiophene or 2,6-divinylbenzenes. The reaction usually gave moderate yields and catalyst-dependent was seen in some cases. The reaction is compatible with other reported dipyrromethane syntheses and could be applied for the construction of unusual porphyrins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8f64970d2ab174f0036d6c1442371ba4 https://doi.org/10.1016/j.tetlet.2008.04.119 Zobrazit plný text záznamu Full Text from ScienceDirect