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Introduction: Hepatitis C is a disease triggered due to an infection by the hepatitis C virus and presents challenges in its treatment, even with the development of multiple direct-acting antivirals agents. Patients with hepatic decompensation or hepatocellular carcinoma and who have experienced treatment failures due to viral variants depend on the development of new molecules, that can be effective as antivirals or with other alternative properties that collaborate to improve symptoms and to avoid or mitigate clinical consequences. Objective: The aim of this review was to verify which new molecules were discovered and can be promising in face of the still persistent challenges in the treatment of hepatitis C. Method: A narrative review was carried out, searching for the specific keywords in PubMed and Google Scholar and molecules with greater potential to meet the demand of difficult to treat patients were selected. Result: The literature search showed that researchers have been engaged in the identification and discovery of new active compounds using various tools for rational drug design, making possible structural modifications that lead to improved effectiveness and pharmacological properties. Conclusion: Several molecules are in the process of being tested to meet the demands of difficult-to-treat patients, including molecules from natural products, and have the potential to help these patients. |
