Making Human Milk Oligosaccharides Available for Research and Application – Approaches, Challenges, and Future Opportunities
Autor: | Richard H. Furneaux, Lars Bode, Joeri Beauprez, Andrew C. Muscroft-Taylor, Stewart Campbell |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Engineering 010405 organic chemistry business.industry Enzymatic synthesis 01 natural sciences Chemical synthesis 0104 chemical sciences Biotechnology 03 medical and health sciences 030104 developmental biology Homogeneous Fermentation Biochemical engineering business health care economics and organizations |
Popis: | Elucidation of the biological roles and more detailed structure–function relationships of human milk oligosaccharides (HMOs) requires access to homogeneous, defined HMO samples. Various approaches, including chemical synthesis, enzymatic/chemoenzymatic synthesis, and fermentation processes, have been developed to support this goal. Examples of scalable industrial processes demonstrating each approach are presented. These strategies, alone and in combination, may be deployed to address the problem of routine access to HMOs for biological and nutritional research and applications. |
Databáze: | OpenAIRE |
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