Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor

Autor:	Jianwei Bian, James Roache, Sisi Zhang, Hui Wang, Jianhua Wang, Hongwei Yang, Tao Hong, Ruowei Mo, Feng Gao, Yizong Zhou, Cary Fridrich, Min Shi, Xiangguang Tian, Bin Wu, Pete Delgado, Jing Guo
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Ketone 010405 organic chemistry Chemistry Organic Chemistry Continuous manufacturing 010402 general chemistry 01 natural sciences Combinatorial chemistry Factor XI inhibitor 0104 chemical sciences Pulmonary surfactant Biocatalysis Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 24:2780-2788
ISSN:	1520-586X 1083-6160
Popis:	The scalable synthesis of an FXI (Factor XI) inhibitor employing multiple emerging technologies is described. The reduction of ketone to chiral alcohol was established through a biocatalysis approa...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8f55cb33f8aba32b377cafb96ac88f81 https://doi.org/10.1021/acs.oprd.0c00412 Zobrazit plný text záznamu