Selective accumulation of [62Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells
| Autor: | Jun Hatazawa, Hiroshi Watabe, Kozi Nakai, Naruto Takahashi, Masao Tanihara, Kiyomi Kakiuchi, Shiho Hirohara, Masato Tamura, Hirofumi Matsui, Yasukazu Kanai |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.diagnostic_test
Chemistry Organic Chemistry Clinical Biochemistry Active stage Analytical chemistry Pharmaceutical Science Cancer Pet imaging medicine.disease Biochemistry Porphyrin In vitro chemistry.chemical_compound Nuclear magnetic resonance In vivo Positron emission tomography Drug Discovery Cancer cell medicine Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry. 22:2563-2570 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2014.02.021 |
| Popis: | Positron-emission tomography (PET) can be used to visualize active stage cancer. Fluorine-18 ([ 18 F])-labeled 2-([ 18 F])2-deoxy-2-fluoroglucose (([ 18 F])-FDG), which accumulates in glucose-dependent tissues, is a good cancer-targeting tracer. However, ([ 18 F])-FDG is obscured in glucose-dependent normal tissues. In this study, we assessed the cancer-selective accumulation of zinc-labeled glycoconjugated 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (ZnGlc 1 – 4 ), both in vitro and in vivo. Experiments using both normal and cancer cells confirmed the relationship between cancer cell-selective accumulation and the substitution numbers and orientations of glycoconjugated porphyrins. ZnGlc trans - 2 accumulated at greater levels in cancer cells compared with other glycoconjugated porphyrins. PET imaging showed that ZnGlc trans - 2 accumulated in tumor. |
| Databáze: | OpenAIRE |
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