Cerebral Blood Flow Declines Independently of Metabolism During Hypothermic Cardiopulmonary Bypass
| Autor: | Donald S. Prough, David A. Stump, Anne T. Rogers, Allen S. Hudspeth |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure business.industry Cerebral metabolic rate Metabolism Hypercarbia law.invention Pump flow Neurologic Dysfunctions Cerebral blood flow law Internal medicine Anesthesia medicine Cardiopulmonary bypass Cardiology business circulatory and respiratory physiology |
| Zdroj: | Impact of Cardiac Surgery on the Quality of Life ISBN: 9781461279082 |
| DOI: | 10.1007/978-1-4613-0647-4_32 |
| Popis: | Although neurologic sequelae are common [1, 2] following nonpulsatile hypothermic cardiopulmonary bypass (CPB), the etiology of neurologic dysfunctions in this setting are still unclear because of the difficulty of monitoring cerebral blood flow (CBF) and cerebral metabolism during the operative procedure. We have used the Xe-133 desaturation method to measure CBF in over 200 patients during CPB to define the cerebrovascular response to a variety of physiological conditions, such as changes in pump flow [3], acid-base management [4, 5], hypercarbia [6], anesthetics [7], and to evaluate the effects of age and cerebrovascular disease [8, 9, 10]. Our studies have demonstrated a spontaneous decline in regional CBF (rCBF) during hypothermic CPB that is independent of the cerebral metabolic rate. |
| Databáze: | OpenAIRE |
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