?1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E ?4 allele carriers
| Autor: | Toshio Ogihara, Aoi Yoshiiwa, H. Yamamoto, T. Kobayashi, Hiroshi Yoneda, Yumiko Nishiwaki, Tetsuro Miki, Hiromi Rakugi, Naoyuki Sato, Kouzin Kamino, Toshiaki Sakai, Yasuhiro Nonomura, Masaki Imagawa |
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| Rok vydání: | 1997 |
| Předmět: |
Apolipoprotein E
Pathology medicine.medical_specialty biology business.industry Odds ratio medicine.disease Alpha 1-antichymotrypsin Minor allele frequency Endocrinology Neurology Internal medicine mental disorders Genotype medicine biology.protein lipids (amino acids peptides and proteins) Neurology (clinical) Alzheimer's disease Allele business Allele frequency |
| Zdroj: | Annals of Neurology. 42:115-117 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.410420118 |
| Popis: | In the Japanese population, sporadic late-onset Alzheimer's disease (LOAD) cases had significantly higher frequencies of the A allele of alpha 1-antichymotrypsin (ACT) gene as well as the epsilon 4 allele of apolipoprotein E (APOE) gene than controls. The odds ratio for LOAD in APOE4 carriers with the ACT-A allele was more than six times that in APOE4 carriers without the ACT-A allele (21.1 vs 3.2). These results indicate that the ACT-A allele is a risk modifier for LOAD in APOE4 carriers. |
| Databáze: | OpenAIRE |
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