Design and Synthesis of Some New 1,4-Benzoxazine-Isoxazole Hybrids as In Vitro Anticancer Agents

Autor:	V. Benarjee, B. B. V. Sailaja, B. Saritha
Rok vydání:	2021
Předmět:	HeLa chemistry.chemical_compound Aqueous solution chemistry biology Ic50 values Regioselectivity General Chemistry Isoxazole biology.organism_classification Combinatorial chemistry In vitro Catalysis
Zdroj:	Russian Journal of General Chemistry. 91:1783-1788
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363221090255
Popis:	Synthesis of twelve novel regioselective 1,4-benzoxazine-isoxazole hybrids as in vitro anticancer agents via Cu(I) catalyzed one-pot reaction of various terminal alkynes with 3-(3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanal in benign aqueous t-butanol at room temperature is presented herein. Five products have demonstrated promising activity, among those the compound 6f demonstrates outstanding activity towards PC3, A549, MCF-7, and HeLa with IC50 values of 2.61, 3.34, 2.74, and 7.04 μM respectively.
Databáze:	OpenAIRE
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