Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model
| Autor: | Tae Gwan Park, Sun Hwa Kim, Yong Min Huh, Donghoon Choi, Jaemoon Yang, Sook Hee Ku, Hyejung Mok, Ji Won Park, Ji Hoon Jeong, Minhyung Lee, Hyung Ho Moon |
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| Rok vydání: | 2013 |
| Předmět: |
Polymers and Plastics
Chemistry Mesenchymal stem cell Ischemia Bioengineering Nanotechnology medicine.disease Cell biology Biomaterials Vascular endothelial growth factor chemistry.chemical_compound In vivo Materials Chemistry medicine Ethylene glycol Intracellular Iron oxide nanoparticles Biotechnology Cerebrovascular Ischemia |
| Zdroj: | Macromolecular Bioscience. 14:380-389 |
| ISSN: | 1616-5187 |
| DOI: | 10.1002/mabi.201300340 |
| Popis: | Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area. |
| Databáze: | OpenAIRE |
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