Acute liver failure following therapeutic paracetamol administration in patients with muscular dystrophies
| Autor: | B. Pearce, I. S. Grant |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
business.industry Analgesic medicine.disease Intensive care unit Gastroenterology law.invention Surgery Malnutrition Anesthesiology and Pain Medicine Fulminant hepatic failure Pharmacokinetics Respiratory failure law Internal medicine Medicine Antipyretic Muscular dystrophy business medicine.drug |
| Zdroj: | Anaesthesia. 63:89-91 |
| ISSN: | 1365-2044 0003-2409 |
| Popis: | Clinically significant liver damage in patients taking therapeutic doses of paracetamol is very rare. We report two cases of fulminant hepatic failure caused by therapeutic (4 g x day(-1)) paracetamol administration on our Intensive Care Unit. Both patients had a muscular dystrophy and presented with a chest infection on a background of endstage neuromuscular respiratory failure. We also noted one further similar case in the literature and suggest a relationship between muscular dystrophy and paracetamol-induced hepatotoxicity. In this report we discuss in detail possible mechanisms that may account for this apparent association, which include altered pharmacokinetics, reduced glutathione stores, malnutrition and hypoxic injury. |
| Databáze: | OpenAIRE |
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