Increasing tensile strength by reducing particle size for extrudate-based tablet formulations
| Autor: | Catherine N. Hallam, Ian Gabbott |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Physics::Instrumentation and Detectors High Energy Physics::Lattice Pharmaceutical Science Rotor speed 02 engineering and technology Die swell 021001 nanoscience & nanotechnology Impact mill 030226 pharmacology & pharmacy law.invention General Relativity and Quantum Cosmology High Energy Physics::Theory 03 medical and health sciences 0302 clinical medicine law Particle-size distribution Ultimate tensile strength Mill Particle size Hammer Composite material 0210 nano-technology |
| Zdroj: | Journal of Drug Delivery Science and Technology. 52:825-830 |
| ISSN: | 1773-2247 |
| DOI: | 10.1016/j.jddst.2019.05.049 |
| Popis: | The effect of milled extrudate particle size on tablet tensile strength was investigated in this study. Parameters used for milling with a hammer impact mill were investigated to give different particle size milled extrudate. Mill screen type and aperture size were varied, along with mill rotor speed and extrudate feed rate to the mill. The results showed that reducing the mill screen aperture size, increasing the mill rotor speed and decreasing the extrudate feed rate led to a reduction in the milled extrudate particle size. Milling using a reduced screen aperture size caused a narrowing of the particle size distribution. A smaller milled extrudate particle size resulted in tablets of a higher tensile strength. This along with a narrowing of the particle size distribution resulted in more uniform tablets, hence less weak points for cracks to propagate, and a stronger tablet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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