Effect of successful renal transplantation on coronary AGE accumulation of uremic heart
| Autor: | Ryouji Nagai, Hidehiko Kashiwabara, Seiji Arita, Kazunobu Yoshimura, Toshio Hasegawa, Kinichi Hamaguti, Hiroyuki Terawaki, Kazuaki Nakajima, Kaoru Sakamoto, Kenichi Yamada, Motonobu Nishimura, Takashi Nakazato, Kosei Horiuchi |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment General Medicine Cardiovascular functions Control subjects Coronary arteries Transplantation Normal renal function medicine.anatomical_structure Internal medicine medicine Cardiology Immunohistochemistry business Dialysis Coronary atherosclerosis |
| Zdroj: | International Congress Series. 1245:183-191 |
| ISSN: | 0531-5131 |
| Popis: | In order to investigate the effect of successful renal transplantation (RTx) on uremic heart, we examined (1) immunohistochemical AGE (CML-AGE) accumulation on cardiac arterial walls from well-functioning RTx patients (n=8), patients on maintenance dialysis (DY) (n=10) and nondiabetic subjects with normal renal function as control (n=7), and (2) the changes in cardiovascular functions before and after RTx. Results: (1) Coronary atherosclerotic lesions were detected in both DY and RTx patients (diffuse intimal thickenings of all patients and partial fatty streaks of two DY patients). (2) In 9 of 10 DY patients, AGE accumulation was observed in coronary arteries (intima or media), although this was true in only two of seven control subjects (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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