In Vitro and In Silico Analysis of Novel ACE-Inhibitory Bioactive Peptides Derived from Fermented Goat Milk
| Autor: | Heena Parmar, Amar Sakure, Subrota Hati |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
In silico Bioengineering 01 natural sciences Biochemistry Tripeptidase activity Analytical Chemistry 03 medical and health sciences fluids and secretions Lactobacillus Drug Discovery Food science Peptide sequence biology 010405 organic chemistry Inoculation Chemistry food and beverages biology.organism_classification In vitro 0104 chemical sciences 030104 developmental biology Ace inhibitory Molecular Medicine Fermentation |
| Zdroj: | International Journal of Peptide Research and Therapeutics. 24:441-453 |
| ISSN: | 1573-3904 1573-3149 |
| DOI: | 10.1007/s10989-017-9630-4 |
| Popis: | In the study, two Lactobacillus cultures i.e. L. casei (NK9) and L. fermentum (LF) were studied for their proteolytic activity, di and tripeptidase activity, ACE-inhibitory activity and peptides production under optimized growth condition from fermented goat milk (Capra aegagrus hircus). NK9 and LF were found to be a strong proteolytic culture with 2.0% rate of inoculation after 48 h. LF (10 kDa retentate) produced maximum peptides among all the retentates of the fermented goat milk. Goat milk fermented with NK9 (10 kDa permeates) exhibited peptide sequence i.e. AFPEHK which had ACE inhibitory activity, matched with goat milk protein databases of AHTPDB. However, L. casei (NK9) and L. fermentum (LF) could be explored for the production of ACE inhibitory peptides from fermented goat milk. |
| Databáze: | OpenAIRE |
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