Monte Carlo simulation of PET images for injection dose optimization
| Autor: | Magdaléna Skopalová, Jiří Dvořák, Otakar Bělohlávek, Jiří Boldyš |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.diagnostic_test
Image quality Computer science Applied Mathematics Monte Carlo method Biomedical Engineering Pet imaging Noise Quality (physics) Computational Theory and Mathematics Dose optimization Positron emission tomography Region of interest Modeling and Simulation medicine Molecular Biology Algorithm Software Simulation |
| Zdroj: | International Journal for Numerical Methods in Biomedical Engineering. 29:988-999 |
| ISSN: | 2040-7939 |
| DOI: | 10.1002/cnm.2527 |
| Popis: | SUMMARY When a patient is examined by positron emission tomography (PET), radiotracer dose amount (activity) has to be determined. However, the rules for activity correction according to patients’ weight used nowadays do not correspond with practical experience. Very high image quality is achieved for slim patients, whereas noisy images are produced for obese patients. There is opportunity to modify the correction rule with the aim to equalize image quality within the broad spectrum of patients and to diminish radiation risk to slim patients, with special importance for children. We have built a model of a particular PET scanner and approximated human trunk, which is our region of interest, by a cylindrical model with segments of liver, outer adipose tissue, and the rest. We have performed Monte Carlo simulations of PET imaging using the GATE simulation package. Under reasonably simplifying assumptions and for special parameters, we have developed curves that recommend amount of injected activity based on body parameters to give PET images of constant quality, the quality being expressed in terms of noise equivalent counts. The dependence qualitatively differs from the rules used in clinical practice nowadays, and the results indicate potential for improvement. Copyright © 2012 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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