AlCl3 induced C-arylation/cyclization in a single pot: a new route to benzofuran fused N-heterocycles of pharmacological interest

Autor:	Ravikumar Kapavarapu, Kishore V. L. Parsa, Raju Adepu, K. Shiva Kumar, K. Krishna Priya, C. Malla Reddy, G. Rama Krishna, D. Rambabu, Manojit Pal
Rok vydání:	2012
Předmět:	chemistry.chemical_compound chemistry Active compound Docking (molecular) Organic Chemistry Drug Discovery Phenols Benzofuran Bond formation Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 53:1134-1138
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.12.096
Popis:	A new and one-pot synthesis of benzofuran fused N-heterocycles has been accomplished via AlCl3-mediated C–C followed by C–O bond formation between 2,3-dichloropyrazine or its derivatives and phenols. The methodology provided novel compounds as potential inhibitors of PDE4B. The single crystal X-ray data of a synthesized benzofuran derivative are presented. Scope of the methodology, in vitro pharmacological data of some of the synthesized compounds, along with docking study of an active compound are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8f18c6033afef9065510a6978b620dfc https://doi.org/10.1016/j.tetlet.2011.12.096 Zobrazit plný text záznamu Full Text from ScienceDirect