Echo Time‐Dependence of Observed LungT1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics
| Autor: | Jens-Peter Schenk, Simon M. F. Triphan, Abdulsattar Alrajab, Mirjam Stahl, Mark O. Wielpütz, Marcus A. Mall, Hans-Ulrich Kauczor, Olaf Sommerburg, Bertram J. Jobst, Monika Eichinger |
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| Rok vydání: | 2020 |
| Předmět: |
Spirometry
education.field_of_study Lung medicine.diagnostic_test business.industry Population Lung Clearance Index medicine.disease Cystic fibrosis 030218 nuclear medicine & medical imaging Correlation 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Medicine Radiology Nuclear Medicine and imaging Stage (cooking) business Nuclear medicine education Perfusion |
| Zdroj: | Journal of Magnetic Resonance Imaging. 52:1645-1654 |
| ISSN: | 1522-2586 1053-1807 |
| Popis: | BACKGROUND Noninvasive monitoring of early abnormalities and therapeutic intervention in cystic fibrosis (CF) lung disease using MRI is important. Lung T1 mapping has shown potential for local functional imaging without contrast material. Recently, it was discovered that observed lung T1 depends on the measurement echo time (TE). PURPOSE To examine TE-dependence of observed T1 in patients with CF and its correlation with clinical metrics. STUDY TYPE Prospective. POPULATION In all, 75 pediatric patients with CF (8.6 ± 6.1 years, range 0.1-23 years), with 32 reexamined after 1 year. FIELD STRENGTH/SEQUENCE Patients were examined at 1.5T using an established MRI protocol and a multiecho inversion recovery 2D ultrashort echo time (UTE) sequence for T1 (TE) mapping at five TEs including TE1 = 70 μs. ASSESSMENT Morphological and perfusion MRI were assessed by a radiologist (M.W.) with 11 years of experience using an established CF-MRI scoring system. T1 (TE) was quantified automatically. Clinical data including spirometry (FEV1pred%) and lung clearance index (LCI) were collected. STATISTICAL TESTS T1 (TE) was correlated with the CF-MRI score, clinical data, and LCI. RESULTS T1 (TE) showed a different curvature in CF than in healthy adults: T1 at TE1 was shorter in CF (1157 ms ± 73 ms vs. 1047 ms ± 70 ms, P |
| Databáze: | OpenAIRE |
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