| Autor: |
Vuga Parpura, Hector S Caceres, Sara A Sims, Lawrence Ver Hoef, Anandh K Ramaniharan, Stacy Merritt, Roxanne F Rezaei, Pradyumna K Bharadwaj, Mary Kate Franchetti, David A Raichlen, Courtney J Jessup, Alex G Hishaw, Emily J Van Etten, Theodore P Trouard, David S Geldmacher, Virginia G Wadley, Noam Alperin, Eric S Porges, Adam J Woods, Ron A Cohen, Bonnie E Levin, Tatjana Rundek, Gene E Alexander, Kristina M Visscher |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.04.10.487750 |
| Popis: |
Episodic memory is widely recognized as a critically important aspect of cognition that is often impacted by cognitive and brain aging. Prior work has shown that episodic memory is related to the presence of teeth-like folds on the dentate gyrus, called dentation. We hypothesized that episodic memory performance relates to overall hippocampal structure (i.e., dentation and volume) in an oldest-old cohort. We used data from the McKnight Brain Aging Registry, which consisted of cognitively healthy 85+-year-old adults. We conducted a canonical correlation analysis on 111 participants between a set of episodic memory tests and a set of characterizations of hippocampal structure. The analysis yielded a strong canonical correlation between episodic memory and hippocampal structure (r = 0.491, p = HighlightsWe characterized hippocampal dentation in a healthy oldest-old sample.Hippocampal structure is related to episodic memory in healthy oldest-old adults.Memory functioning is related to both hippocampal volume and dentation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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