The third quorum-sensing system of Pseudomonas aeruginosa: Pseudomonas quinolone signal and the enigmatic PqsE protein
Autor: | Miguel Cocotl-Yañez, Gloria Soberón-Chávez, Selene García-Reyes |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) biology Pseudomonas aeruginosa Operon 030106 microbiology Pseudomonas Virulence General Medicine medicine.disease_cause biology.organism_classification Microbiology Pseudomonas quinolone signal 03 medical and health sciences chemistry.chemical_compound Quorum sensing 030104 developmental biology Pyocyanin chemistry medicine Transcriptional regulation |
Zdroj: | Journal of Medical Microbiology. 69:25-34 |
ISSN: | 1473-5644 0022-2615 |
Popis: | Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors such as lectin A, pyocyanin, elastase and rhamnolipids. These compounds are controlled transcriptionally by three quorum-sensing circuits, two based on the synthesis and detection of N-acyl-homoserine-lactone termed the Las and Rhl system and a third system named the Pseudomonas quinolone signal (PQS) system, which is responsible for generating 2-alkyl-4(1 h)-quinolones (AQs). The transcriptional regulator called PqsR binds to the promoter of pqsABCDE in the presence of PQS or HHQ creating a positive feedback-loop. PqsE, encoded in the operon for AQ synthesis, is a crucial protein for pyocyanin production, activating the Rhl system by a still not fully understood mechanism. In turn, the regulation of the PQS system is modulated by Las and Rhl systems, which act positively and negatively, respectively. This review focuses on the PQS system, from its discovery to its role in Pseudomonas pathogenesis, such as iron depletion and pyocyanin synthesis that involves the PqsE protein - an intriguing player of this system. |
Databáze: | OpenAIRE |
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